6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H) -otu

Ụdị kemịkal

6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H) -otu bụ mmiri mmiri transperent na-enweghị agba na-acha odo odo, nke na-adịghị edozi na mmiri, soluble na CHCl₃, nchekwa kwesịrị ka oyi kpọnwụrụ, kewapụ ya na oxidants, kemịkalụ oriri, pụọ na ọkụ, isi iyi ọkụ.

Ngwa

6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H) -otubụ ihe dị n'etiti Alectinib, onye na-emechi ihe anaplastic lymphoma kinase (ALK) na-ahọrọ nke ukwuu na nke nwere ike igbochi mutant nche ọnụ ụzọ na-eguzogide ọgwụ, nke na-ebute mbelata uto cell.

Ụdị anụ ahụ

Mmiri mmiri na-enweghị isi na-acha odo odo

Ndụ nchekwa

Dabere na ahụmịhe anyị, enwere ike ịchekwa ngwaahịa ahụ maka awa 12ọnwa site na ụbọchị nnyefe ma ọ bụrụ na edobere ya na arịa ndị a kpuchiri ekpuchi, chebe ya pụọ ​​​​na ọkụ na okpomọkụ ma chekwaa ya na okpomọkụ n'etiti 5 -30°C.

TNjirimara pụrụ iche

Ebe esi nri

354.7±42.0 °C na 760 mmHg

Ebe mgbari

168.3± 27.9 °C

Kpọmkwem Mas

282.025543

PSA

26.30000

LogP

3.25

Uzuoku Nrụgide

0.0±0.8 mmHg na 25°C

Index nke ntụgharị uche

1.545

pka

1.26± 0.10 (buru amụma)

Mmiri Solubility

50 mg / ml na CHCl₃