Ụzọ atọ na-atọ ụtọ ndị chemists rụrụ ogige n'afọ a
nke Bethany Halford dere
ENZYMES WURU BOND BIARYL
Atụmatụ na-egosi njikọ nke biaryl nke na-eme ka enzyme-catalyzed.
Ndị na-ahụ maka ọgwụ na-eji molecules biaryl, bụ ndị na-egosipụta otu aryl nke jikọtara ibe ha site na otu njikọ, dị ka chiral ligands, ihe eji ewu ụlọ, na ọgwụ.Mana ime ka motif biaryl jiri mmeghachi omume metal-catalyzed, dị ka Suzuki na Negishi cross-couplings, na-achọkarị ọtụtụ usoro sịntetịt iji mee ndị mmekọ.Kedu ihe ọzọ, mmeghachi omume metal-catalyzed ndị a na-akụda mgbe ha na-eme biaryls buru ibu.Site n'ike mmụọ nke enzymes nwere ike ime ka mmeghachi omume ya pụta, otu ndị Mahadum Michigan's Alison RH Narayan duziri jiri evolushọn eduzi mepụta enzyme cytochrome P450 nke na-ewulite molecule biaryl site na njikọta oxidative nke njikọ carbon-hydrogen aromatic.Enzyme ahụ na-alụ ụmụ irighiri ihe na-esi ísì ụtọ iji mepụta otu stereoisomer gburugburu njikọ nwere ngbanwe na-egbochi (gosiri).Ndị nyocha ahụ chere na ụzọ biocatalytic a nwere ike ịghọ mgbanwe achịcha na bọta maka ime njikọ biaryl (Nature 2022, DOI: 10.1038 / s41586-021-04365-7).
Ntụziaka maka TERTIARY AMINES tụkwasịrị obi na ntakịrị nnu
Atụmatụ na-egosi mmeghachi omume nke na-eme amines dị elu site na nke abụọ.
Ịgwakọta ihe igwe na-agụ agụụ eletrọn na amines bara ụba nke eletrọn na-egbukarị ihe ndị na-akpata, yabụ enweghị ike iji igwe reagents wuo amines nke atọ sitere na amines nke abụọ.M. Christina White na ndị ọrụ ibe na Mahadum Illinois Urbana-Champaign ghọtara na ha nwere ike nweta gburugburu nsogbu a ma ọ bụrụ na ha gbakwunyere ụfọdụ nnu sizinin ha reactant uzommeputa.Site n'ịgbanwe amines nke abụọ ka ọ bụrụ nnu ammonium, ndị na-ahụ maka kemịkalụ chọpụtara na ha nwere ike meghachi omume ogige ndị a na olefins ọnụ, oxidant, na palladium sulfoxide catalyst iji mepụta amines tertiary dị iche iche nwere ụdị ọrụ dị iche iche (ihe atụ gosiri).Ndị chemists jiri mmeghachi omume ahụ mee ka ọgwụ antipsychotic Abilify na Semap na gbanwee ọgwụ ndị dị ugbu a bụ amines nke abụọ, dị ka antidepressant Prozac, n'ime amines nke atọ, na-egosipụta ka ndị chemist nwere ike isi mee ọgwụ ọhụrụ site na ndị dị adị (Science 2022, DOI: 10.1126/sayensị.abn8382).
AZAARENES KWESỊRỊ RỊRỊ KARON
Atụmatụ na-egosi quinoline N-oxide gbanwere ka ọ bụrụ N-acylindole.
N'afọ a, ndị na-ahụ maka kemịkalụ gbakwunyere n'akwụkwọ edezi molekụla, nke bụ mmeghachi omume na-eme mgbanwe na isi nke ụmụ irighiri ihe dị mgbagwoju anya.N'otu ihe atụ, ndị nchọpụta mepụtara mgbanwe nke na-eji ìhè na acid were chịpụ otu carbon n'ime azaarenes nwere akụkụ isii na quinoline N-oxides iji mepụta N-acylindoles nwere mgbanaka nwere akụkụ ise (ihe atụ gosiri).Mmeghachi omume, nke chemists mepụtara na otu Mark D. Levin na Mahadum Chicago, dabere na mmeghachi omume nke metụtara oriọna mercury, nke na-ewepụta ìhè dị iche iche.Levin na ndị ọrụ ibe ya chọpụtara na iji diode na-eme ka ọkụ na-enwu ọkụ na 390 nm nyere ha njikwa ka mma ma kwe ka ha mee mmeghachi omume n'ozuzu maka quinoline N-oxides.Mmeghachi omume ọhụrụ ahụ na-enye ndị na-emepụta molekul ụzọ ha ga-esi megharịa cores nke ogige dị mgbagwoju anya ma nwee ike inyere ndị na-ahụ maka ọgwụ na-achọ ịgbasa ọba akwụkwọ ha nke ndị na-achọ ọgwụ (Sayensị 2022, DOI: 10.1126/science.abo4282).
Oge nzipu: Dec-19-2022